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VON WILLEBRAND FACTOR
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DeCS
Descriptor
English
:
von Willebrand Factor
Descriptor
Spanish
:
factor de von Willebrand
Descriptor
Portuguese
:
Fator de von Willebrand
Synonyms
English
:
Factor VIII Related Antigen
Factor VIII-Related Antigen
Factor VIIIR Ag
Factor VIIIR RCo
Factor VIIIR-Ag
Factor VIIIR-RCo
Plasma Factor VIII Complex
Ristocetin Cofactor
Ristocetin Willebrand Factor
Ristocetin-Willebrand Factor
von Willebrand Protein
Tree Number:
D12.776.124.125.920
D23.119.985
Definition
English
:
A high-molecular-weight
plasma
protein, produced by
endothelial cells
and
megakaryocytes
, that is part of the factor VIII/von Willebrand factor complex. The
von Willebrand factor
has receptors for
collagen
, platelets, and
ristocetin
activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to
collagen
and hemostatic plug formation. The prolonged
bleeding time
in
VON WILLEBRAND DISEASES
is due to the deficiency of this factor.
Indexing Annotation
English
:
/ defic = VON WILLEBRAND
DISEASE
or specific type of Von Willebrand
Disease
See Related
English
:
Coagulants
Weibel-Palade Bodies
von Willebrand Disease, Type 1
von Willebrand Disease, Type 2
von Willebrand Disease, Type 3
von Willebrand Diseases
History Note
English
:
86(76); was see under BLOOD COAGULATION FACTORS 1976-85; FACTOR VIII RELATED ANTIGEN, previously in the Supplementary Chemical File, was mapped to both FACTOR VIII & ANTIGENS 1977-89
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22305
Unique Identifier:
D014841
Occurrence in VHL
:
Similar:
DeCS